Prolonged Shape six
Modules in males and females with MDD are enriched for cell-type specific genes. Stacked bar graphs showing modules enriched for genes expressed in particular cell types in a, male MDD and b, female MDD. The y axis represents module size defined by number of genes within each module. Modules are defined by an arbitrary color name and are clustered by module differential connectivity (MDC) as gain of connectivity (GOC), loss of connectivity (LOC) and conserved. There is no module associated with a LOC in females with MDD. Enrichment is determined by corrected Fisher’s Exact Test p-value and is listed only for modules that reached significance (FDR p<0.05).
Extended Contour 7
Gene co-expression modules in males with MDD are enriched for DEGs across brain regions. a, Topological overlap matrix (TOM) plots for control and b, MDD modules in males. Light color represents low topological overlap and progressively darker red color represents higher overlap. Each module is assigned by a unique color. c, Circos plots displaying the degree of enrichment for DEGs (p<0.05)>Extended Figure 8
a, Schematic image of your own behavioural paradigm regularly measure the perception off DUSP6 downregulation regarding the vmPFC of females. Behavioural effects off DUSP6 downregulation within the lady vmPFC on b, pressed move attempt (FST), c, open-field try (OFT), and you may d, elevated as well as maze (EPM). e, Schematic symbol of one’s behavioural paradigm always assess the impact out of DUSP6 overexpression in females adopting the sub-persistent variable be concerned. Bottom graph shows new HSV-mediated overexpression from DUSP6 covering the infra- and you may prelimbic region of the vmPFC within the mice. Behavioural effects out-of DUSP6 widespread overexpression regarding the f, novelty-supressed eating decide to try (NSF) and you can grams, sucrose liking decide to try. Lire la suite